尹恒
出生年月：1982.10
工作单位：中国科学院大连化学物理研究所
职称/职务：研究员/研究组组长
地址：大连化物所1805组，辽宁省大连市中山路457号，116023
电话：0411-84379061；邮箱：yinheng@dicp.ac.cn
个人简介
尹恒，研究员，博导，中科院青年创新促进会优秀会员、大连化物所“张大煜优秀学者”、首席研究员。现任天然产物及糖工程研究组组长，辽宁省碳水化合物研究重点实验室主任，大连市糖类农用制剂工程研究中心主任。
1982年10月生，2003年毕业于大连理工大学精细化工专业获学士学位；2008年毕业于中科院大连化物所生物化工专业获博士学位，期间于2004-2006年在复旦大学糖复合物卫生部重点实验室进行联合培养。毕业后留所工作至今，其间于2010-2011年在丹麦奥胡斯大学做访问学者。2011年任副研究员，2015年任研究员。
研究方向主要为糖工程及酶工程、糖生物学及植物免疫。在糖工程领域，致力于将天然碳水化合物资源转化为功能产品或能源产品，重点研究如何绿色高效的从多糖降解制备得到寡糖，并对此过程中重要的生物酶进行创制及机制研究。开发得到海藻酸钠裂解酶、葡聚糖酶等多种新型多糖降解酶，这些酶除应用于功能寡糖生产外，已与知名酶制剂公司合作开发产品，进入市场。通过酶法制备得到海藻酸钠寡糖等系列寡糖，通过和企业合作，开发生物农药、肥料多种获农药登记证等国家相关证书，在全国多地多种作物上实现了寡糖农用制剂大规模推广应用，产生较大社会与经济效益；相关产品已在东南亚一带一路国家及美国投入应用。在糖生物学领域，主要研究植物中糖基化修饰等基础糖生物学问题，解析植物体内重要单糖的合成途径并明确途径中关键酶的功能；研究外源寡糖在植物上调节植物免疫作用的功能、机制与应用，系统研究了寡糖激活植物免疫诱导植物抗病的作用机制。
累计主持“一带一路”科学联盟合作专项、国家重点研发计划课题、国家自然科学基金、中科院STS、企业横向等30余项课题。主编外文专著一部，参与编著中文著作四部，发表SCI论文百余篇（其中中科院一区40余篇），授权专利34项，已实现转化应用10项。担任科技部“生物农药与生物防治产业技术创新战略联盟”副理事长、全国农药标委会生物农药分委会委员、中国生物工程学会糖生物工程专委会委员、中国生化与分子生物学会糖复合物专委会委员、中国生物物理学会糖生物学专委会委员、中国植物保护学会生物防治专委会委员等学术兼职。入选中科院青促会优秀会员、辽宁省百千万人才百层次、兴辽英才、大连市杰出青年科技人才等人才项目；获得海洋科学技术奖一等奖、辽宁省科技进步二等奖、张树政糖科学奖优秀青年奖等科技奖励。
研究工作经历
2015/07-，中科院大连化物所，研究员、研究组组长;
2015/05-2015/07，中科院大连化物所，副研究员、研究组组长;
2013/05-2015/05，中科院大连化物所，副研究员、研究组召集人;
2012/01-2013/05，中科院大连化学物理研究所生物技术部，副研究员、研究组组副组长
2011/10-2012/01，中国科学院大连化学物理研究所，生物技术部，副研究员
2008/09-2011/10，中国科学院大连化学物理研究所，生物技术部，助研，其中：
2010/03-2011/02，丹麦奥胡斯大学，食品科学系，公派访问学者
受教育经历
2003/09-2008/08，中国科学院大连化学物理研究所，生物化工，硕博连读，其中：
2003/09-2004/09, 中国科学院研究生院基础课学习
2004/12-2006/08, 复旦大学上海医学院基因中心联合培养
1999/09-2003/06，大连理工大学，化工学院，学士
期刊论文
111 Zhongbin Xiao,Ming Sun,Tang Li,Miao Zhao,Heng Yin.Mannuronan C-5 Epimerases: Review of Activity Assays, Enzyme Characteristics, Structure, and Mechanism.Catalysts, 2023,13(1), 28
2022
110 Yijie Dong, Tang Li, Shiqing Zhang, Joaquin Sanchis, Heng Yin, Jie Ren, Xiang Sheng, Guangyue Li, Manfred T. Reetz.Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates. ACS Catalysis. 2022, 12, 6, 3669–3680.
109 Lingfeng Long, Yun Hu, Fubao Sun, Wa Gao, Zhikui Hao, Heng Yin. Advances in lytic polysaccharide monooxygenases with the cellulose-degrading auxiliary activity family 9 to facilitate cellulose degradation for biorefinery. International Journal of Biological Macromolecules, 2022, 219, 68-83
108 En Yu, Daiwen Chen, Bing Yu, Zhiqing Huang, Xiangbing Mao, Ping Zheng, Yuheng Luo, Heng Yin, Jie Yu, Junqiu Luo, Hui Yan, Jun He.Alteration of Porcine Intestinal Microbiota in Response to Dietary Manno-Oligosaccharide Supplementation.Frontiers in Microbiology, 2022, 811272,1-11
107 Can Zhao, Chunyan Wu,Kuikui Li, John F. Kennedy, Michael Wisniewski, Lihong Gao，Chenggui Han, Jia Liu, Heng Yin, Xuehong Wu.Effect of Oligogalacturonides on Seed Germination and Disease Resistance of Sugar Beet Seedling and Root.Journal of Fungi, 2022, 8, 716, 1-13
106 Ruixin Li, Maolong Li, Jinxia He, Hongguo Xie, Wenxia Wang, Meng Zhang, Gustavo Cabrera-Barjas, Pierfrancesco Morganti, Heng Yin.Preparation of Pectin Nanospheres and Its Effect on Wheat (Triticum aestivum L.) Seed Germination and Growth.Journal of Plant Growth Regulation, 2022. 41: 3197–3207
105 Kuikui Li, Chunlai Zhang, Wenxia Wang, Changzheng Chen, Qishun Liu, Heng Yin.First Report of Neopestalotiopsis clavispora Causing Postharvest Fruit Rot on Actinidia arguta in Liaoning Province, China.Plant Disease, 2022,doi: 10.1094/PDIS-01-22-0240-PDN
104 Wa Gao, Hefeng Zhang, Tang Li, Jiu Ju, Haichuan Zhou, Xu Zong, Heng Yin.Controlled depolymerization of cellulose by photoelectrochemical bioreactor using a lytic polysaccharide monooxygenase.Biochemical Engineering Journal, 2022, 187, 108597（1-6）
103 Huiyan Zhang, Haichuan Zhou, Yong Zhao, Tang Li , Heng Yin.Comparative studies of two AA10 familylytic polysaccharide monooxygenasesfrom Bacillus thuringiensis.Peer J, 2022 DOI 10.7717/peerj.14670
2021
102 Xiao Yin, HongguoXie, Ruixin Li, Shenggang Yan, Heng Yin. Regulating association strength between quaternary ammonium chitosan and sodium alginate via hydration. Carbohydrate Polymers. 2021, 255(117390): 1-8.
101 Jin Wan, Jiao Zhang, Qingsong Xu, Heng Yin, Daiwen Chen, Bing Yu, Jun He. Alginate oligosaccharide protects against enterotoxigenic Escherichia coli-induced porcine intestinal barrier injury. Carbohydrate Polymers. 2021, 270(118316): 1-12.
100 Tang Li, Ningning Zhang, Shenggang Yan, Shan Jiang, Heng Yin. A Novel Tyrosinase from Armillaria ostoyae with Comparable Monophenolase and Diphenolase Activities Suffers Substrate Inhibition. Applied and Environmental Microbiology. 2021, 87(12): 1-14.
99 Guojun Yang, Shuguang Li, Haidong Tan, Kuikui Li, Wei Chen, Heng Yin. A Highly Efficient Biocatalytic Conversion of Renewable Pectic Polysaccharide Biomass into Bioactive Oligogalacturonides. ACS Food Science & Technology. 2021, 1(3): 338-346.
98 Yu Wang, Xue Sun, XiaochenJia, Liping Zhu, Heng Yin. Comparative transcriptomic of Stevia rebaudiana provides insight into rebaudioside D and rebaudioside M biosynthesis. Plant Physiology and Biochemistry. 2021, 167. 541-549.
97 Qian Li, Chaofeng Jiang, Haidong Tan, Xiaoming Zhao, Kuikui Li, Heng Yin. Characterization of recombinant E. coli expressing a novel fucosidase from Bacillus cereus 2-8 belonging to GH95 family. Protein Expression and Purification. 2021, 105897: 1-7.
96 En Yu, Daiwen Chen, Bing Yu, Zhiqing Huang, Xiangbing Mao, Ping Zheng, Yuheng Luo, Heng Yin, Jie Yu, Junqiu Luo, Hui Yan, Jun He. Manno-oligosaccharide attenuates inflammation and intestinal epithelium injury in weaned pigs upon enterotoxigenic Escherichia coli K88 challenge. British Journal of Nutrition. 2021, 126(7): 993-1002.
95 En Yu, Daiwen Chen, Bing Yu, Yuheng Luo, Ping Zheng, Heng Yin, Xiangbing Mao, Zhiqing Huang, Jie Yu, Junqiu Luo, HuiYan, Jun He. Amelioration of enterotoxigenic Escherichia coli-induced disruption of intestinal epithelium by manno-oligosaccharide in weaned pigs. Journal of Functional Foods. 2021, 82(104492): 1-10.
94 Gustavo Cabrera-Barjas, Cristian González, Aleksandra Nesic, Kelly P. Marrugo, Oscar Gómez, Cédric Delattre, Oscar Valdes, Heng Yin, Gaston Bravo, Juan Cea. Utilization of Marine Waste to Obtain β-Chitin Nanofibers and Films from Giant Humboldt Squid Dosidicus gigas. Marine Drugs. 2021, 1-18.
93 Kuikui Li, Chaofeng Jiang, Haidong Tan, Junyan Li, Yali Xu, Dejian Tang, Xiaoming Zhao, Qishun Liu, Jianguo Li, Heng Yin. Identification and characterization of a novel glucomannanase from Paenibacilluspolymyxa. 3 Biotech. 2021, 11(129): 1-11.
2020
92 Hefeng Zhang, Yong Zhao, Huiyan Zhang, Haichuan Zhou, Hong Wang, Xu Zong, Heng Yin, Can Li. Establishing inorganic-biological hybrid photoelectrochemical platform towards sustainable conversion of α-chitin. Applied Catalysis B: Environmental. 2020, 265(118): 558.
91 Haichuan Zhou, Yuebin Zhang, Tang Li, Haidong Tan, Guohui Li, Heng Yin. Distinct Interaction of Lytic Polysaccharide Monooxygenase with Cellulose Revealed by Computational and Biochemical Studies. Journal of Physical Chemistry Letters. 2020, 11: 3987-3992.
90 Xiaochen Jia, Haihong Zeng, Santosh Kumar Bose, Wenxia Wang, Heng Yin.Chitosan oligosaccharide induces resistance to Pst DC3000 in Arabidopsis via a non-canonical N-glycosylation regulation pattern. Carbohydrate Polymers. 2020, 250: 116939.
89 Jia Liu, John F. Kennedy, Xiaofang Zhang, Heng Yin, Wei Chen, Zhuo Chen, Xian Wu, Xuehong Wu. Preparation of alginate oligosaccharide and its effects on decay control and quality maintenance of harvested kiwifruit. Carbohydrate Polymers. 2020, 242: 116462.
88 Santosh Kumar Bose, PriankaHowlader, Wenxia Wang, Heng Yin. Oligosaccharide is a promising natural preservative for improving postharvest preservation of fruit: A review. Food Chemistry. 2020, 341: 128178.
87 Guojun Yang, Wei Chen, Haidong Tan, Kuikui Li, Junyan Li, Heng Yin. Biochemical characterization and evolutionary analysis of a novel pectate lyase from Aspergillus parasiticus. International Journal of Biological Macromolecules. 2020, 152: 180-188.
86 Junjie Liu, Chunguang Zhang, Xiaochen Jia, Wenxia Wang, Heng Yin. Comparative analysis of RNA-binding proteomes under Arabidopsis thaliana-Pst DC3000-PAMP interaction by orthogonal organic phase separation. International Journal of Biological Macromolecules. 2020, 160: 47-54.
85 PriankaHowlader, Santosh Kumar Bose, Xiaochen Jia, Chunlai Zhang, Wenxia Wang, Heng Yin. Oligogalacturonides induce resistance in Arabidopsis thaliana by triggering salicylic acid and jasmonic acid pathways against Pst DC3000.International Journal of Biological Macromolecules. 2020, 164: 4054-4064.
84 Ming Sun, Chu Sun, Tang Li, Kuikui Li, Shenggang Yan, Heng Yin. Characterization of a novel bifunctional mannuronan C-5 epimerase and alginate lyase from Pseudomonas mendocina. sp. DICP-70. International Journal of Biological Macromolecules. 2020, 150: 662–670.
83 Qing Hu, Xiaoqing Guan, Lilin Song, Haonan Wang, Yuan Xiong, Junling Liu, Heng Yin, Yunfeng Cao, Jie Hou, Ling Yang, Guangbo Ge. Inhibition of pancreatic lipase by environmental xenoestrogens. Ecotoxicology and Environmental Safety. 2020, 192: 110305.
82 Ruixin Li, HongguoXie, Chunguang Zhang, Yeqing Sun, Heng Yin. ROS-Responsive Polymeric Micelle for Improving Pesticides Efficiency and Intelligent Release. Journal of Agricultural and Food Chemistry. 2020, 68: 9052-9060.
81 Junyan Ma, Tang Li, Haidong Tan, Wujun Liu, Heng Yin. The Important Roles Played in Substrate Binding of Aromatic Amino Acids in Exo-Inulinase from Kluyveromycescicerisporus CBS 4857. Frontiers in Molecular Biosciences. 2020, 7: 569797.
80 Lei Liu, Daiwen Chen, Bing Yu, Heng Yin, Zhiqing Huang, Yuheng Luo, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Hui Yan, Jun He. Fructooligosaccharides improves growth performance and intestinal epithelium function in weaned pigs exposure to Enterotoxigenic Escherichia coli. Food & Function. 2020, DOI: 10.1039/d0fo01998d.
79 Fu Hu, Benwei Zhu, Qian Li, Heng Yin, Yun Sun, Zhong Yao, Dengming Ming. Elucidation of a Unique Pattern and the Role of Carbohydrate Binding Module of an Alginate Lyase. Marine Drugs. 2020, 18: 32.
78 Jin Wan, Jiao Zhang, Heng Yin, Daiwen Chen, Bing Yu, Jun He. Ameliorative effects of alginate oligosaccharide on tumour necrosis factor-α-induced intestinal epithelial cell injury. International Immunopharmacology. 2020, 89: 107084.
77 Xiaochen Jia, Hongqiang Qin, Santosh Kumar Bose, Tongmei Liu, Jinxia He, ShangqiangXie, Mingliang Ye, Heng Yin. Proteomics analysis reveals the defense priming effect of chitosan oligosaccharides in Arabidopsis-Pst DC3000 interaction. Plant Physiology and Biochemistry. 2020, 149: 301–312.
76 Kuikui Li, Huan Qi, Qishun Liu, Tang Li, Wei Chen, Shuguang Li, Hai-long Piao, Heng Yin. Preparation and antitumor activity of selenium-modified glucomannan oligosaccharides. Journal of Functional Foods. 2020, 65: 103731.
75 PriankaHowlader, Santosh Kumar Bose, Chunguang Zhang, Xiaochen Jia, Wenxia Wang, Heng Yin. Pectin oligosaccharide (POS) induce resistance in Arabidopsis thaliana through salicylic acid-mediated signaling pathway against Pseudomonas syringaepv. tomato DC3000. Physiological and Molecular Plant Pathology. 2020, 110: 101483.
74 Chunguang Zhang, Wenxia Wang, Xiaoming Zhao, Hongying Wang, Heng Yin. Preparation of alginate oligosaccharides and their biological activities in plants: A review. Carbohydrate Research. 2020, 494: 108056.
73 Xiaochen Jia, Mijanur Rahman Rajib, Heng Yin. Recognition pattern, functional mechanism and application of chitin and chitosan oligosaccharides in sustainable agriculture. Current Pharmaceutical Design. 2020, 26: 1-14.
72 Shuli Wu, Qishun Liu, Haidong Tan, Fuyun Zhang, Heng Yin. A Novel 2,5-Furandicarboxylic Acid Biosynthesis Route from Biomass-Derived 5-Hydroxymethylfurfural Based on the Consecutive Enzyme Reactions. Applied Biochemistry and Biotechnology. 2020, 3290.
71 Santosh Kumar Bose, Yanqiu He, PriankaHowlader, Wenxia Wang, Heng Yin. The N-glycan processing enzymes beta-D-N-acetylhexosaminidase are involved in ripening-associated softening in strawberry fruit. Journal of Food Science and Technology. 2020, 4576.
70 Haidong Tan, Heng Yin. Optimization and characterization of oligosaccharides production from citrus peel waste resource using Aspergillus niger 1805. Journal of Microbiological Methods. 2020, 169: 105809.
69 Haidong Tan, Guojun Yang, Wei Chen, Qishun Liu, Kuikui Li, Heng Yin. Identification and characterization of thermostable endo-polygalacturonase II B from Aspergillus luchuensis. Journal of Food Biochemistry. 2020, 13133.
2019
68 Guojun Yang, Haidong Tan, Shuguang Li, Meng Zhang, Jia Che, Kuikui Li, Wei Chen, Heng Yin. Application of engineered yeast strain fermentation for oligogalacturonides production from pectin-rich waste biomass. Bioresource Technology. 2019, 300(122): 645.
67 Chunguang Zhang, PriankaHowlader, Tongmei Liu, Xue Sun, Xiaochen Jia, Xiaoming Zhao, Peili Shen, Yimin Qin, Wenxia Wang, Heng Yin. Alginate Oligosaccharide (AOS) induced resistance to Pst DC3000 via salicylic acid-mediated signaling pathway in Arabidopsis thaliana. Carbohydrate Polymers. 2019, 225(115):221.
66 Santosh kumar Bose, PriankaHowlader, Xiaochen Jia, Wenxia Wang, Heng Yin. Alginate oligosaccharide postharvest treatment preserve fruit quality and increase storage life via Abscisic acid signaling in strawberry. Food Chemistry. 2019, 283: 665-674.
65 Qishun Liu, Changhong Yao, Yongxin Sun, Wei Chen, Haidong Tan, Xupeng Cao, Song Xue, Heng Yin. Production and structural characterization of a new type of polysaccharide from nitrogen-limited Arthrospira platensis cultivated in outdoor industrial-scale open raceway ponds. Biotechnology For Biofuels. 2019, 12:131.
64 Haichuan Zhou, Tang Li, Zuochen Yu, Jiu Ju, Huiyan Zhang, Haidong Tan, Kuikui Li, Heng Yin. A lytic polysaccharide monooxygenase from Myceliophthorathermophila and its synergism with cellobiohydrolases in cellulose hydrolysis. International Journal Of Biological Macromolecules. 2019, 139: 570-576.
63 Benwei Zhu, Kuikui Li, Wenxia Wang, Limin Ning, Haidong Tan, Xiaoming Zhao, Heng Yin. Preparation of trisaccharides from alginate by a novel alginate lyase Alg7A from marine bacterium Vibrio sp. W13. International Journal of Biological Macromolecules. 2019, 139: 879-885.
62 Ruixin Li, Jinxia He, HongguoXie, Wenxia Wang, Santosh kumar Bose, Yeqing Sun, Jianen Hu, Heng Yin. Effects of chitosan nanoparticles on seed germination and seedling growth of wheat (Triticum aestivum L.). International Journal of Biological Macromolecules. 2019, 126: 91-100.
61 Junyan Ma, Qian Li, Haidong Tan, Hao Jiang, Kuikui Li, Lihua Zhang, Quan Shi, Heng Yin. Unique N-glycosylation of a recombinant exo-inulinase from Kluyveromycescicerisporus and its effect on enzymatic activity and thermostability. Journal of Biological Engineering. 2019, 13:81.
60 Xianyu Zhu, Yong Zhao, Huaidong Zhang, Wenxia Wang, Haihua Cong, Heng Yin. Characterization of the Specific Mode of Action of a Chitin Deacetylase and Separation of the Partially Acetylated Chitosan Oligosaccharides. Marine Drugs. 2019, 17:74.
59 Yanqiu He, Santosh kumar Bose, Mengyu Wang, Tongmei Liu, Wenxia Wang, Hang Lu, Heng Yin. Effects of chitosan oligosaccharides postharvest treatment on the quality and ripening related gene of cultivated strawberry fruits. Journal of Berry Research. 2019, 9(1): 11-25.
58 Fengqin Gong, Qishun Liu, Haidong Tan, Tang Li, Chengyu Tan, Heng Yin. Cloning, expression and characterization of a novel (2R,3R) -2,3-butanediol dehydrogenase from Bacillus thuringiensis. Biotechnology, Biocatalysis and Agricultural. 2019, 22(101): 372.
57 Ming Sun, Chu Sun, HongguoXie, Shenggang Yan, Heng Yin. A simple method to calculate the degree of polymerization of alginate oligosaccharides and low molecular weight alginates. Carbohydrate Research. 2019, 486(107):856.
56 Junping Zheng, X Yuan, C Zhang, Peiyuan Jia, Siming Jiao, Xiaoming Zhao, Heng Yin, Yuguang Du, Hongtao Liu. N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic disorder in high-fat diet-fed mice. Journal of Diabetes. 2019, 11(1): 32-45.
55 Hongyan Zhang, Heng Yin, GuojieJin. Function of Nitric Oxide in Chitosan Oligosaccharide-Induced Resistance to Tobacco Mosaic Virus. International Journal of Agriculture and Biology. 2019, 21(1): 85-92.
2018
54 Kuikui Li, Wei Chen, Wenxia Wang, Haidong Tan, Shuguang Li, Heng Yin. Effective degradation of curdlan powder by a novel endo-β-1,3-glucanase. Carbohydrate Polymers. 2018, 201: 122-130.
53 Junping Zheng, Xubing Yuan, Gong Cheng, Siming Jiao, Cui Feng, Xiaoming Zhao, Heng Yin, Yuguang Du, Hongtao Liu. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice. Carbohydrate Polymers. 2018, 190: 77-86.
52 Xiaochen Jia, Haihong Zeng, Wenxia Wang, Fuyun Zhang, Heng Yin. Chitosan oligosaccharide induces resistance to Pseudomonas syringaepv. tomato DC3000 in Arabidopsis thaliana by activating both salicylic acid- and jasmonic acid-mediated pathways. Molecular Plant-Microbe Interactions. 2018, 31(12): 1271-1279.
51 Benwei Zhu, Fang Ni, Yun Sun, Xianyu Zhu, Heng Yin, Zhong Yao, Yuguagn Du. Insight into carrageenases: major review of sources, category, property, purification method, structure, and applications. Critical Reviews in Biotechnology. 2018, 1-16.
50 Zuochen Yu, Benwei Zhu, Wenxia Wang, Haidong Tan, Heng Yin. Characterization of a new oligoalginate lyase from marine bacterium Vibrio sp. International Journal of Biological Macromolecules. 2018, 112: 937-942.
49 Dongdong Liu, Siming Jiao, Gong Cheng, XLi, Zhichao Pei, Yuxin Pei, Heng Yin, Yuguang Du. Identification of chitosan oligosaccharides binding proteins from the plasma membrane of wheat leaf cell. International Journal of Biological Macromolecules. 2018, 111: 1083-1090.
48 Yanqiu He, Santosh Kumar Bose, Wenxia Wang, Xiaochen Jia, Hang Lu, Heng Yin. Pre-Harvest Treatment of Chitosan Oligosaccharides Improved Strawberry Fruit Quality. International Journal of Molecular Sciences, 2018, 19: 2194.
47 Junping Zheng, Gong Cheng, Qiongyu Li, Siming Jiao, Cui Feng, Xiaoming Zhao, Heng Yin, Yuguang Du, Hongtao Liu. Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice. Marine Drugs. 2018, 16:1-17.
46 Junping Zheng, Siming Jiao, Qiongyu Li, Peiyuan Jia, Heng Yin, Xiaoming Zhao, Yuguang Du, Hongtao Liu. Antrodiacinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation. Molecules. 2018, 23: 1-16.
45 C Badiali, GD Angelis, G Simonetti, E Brasili, EDC Tobaruela, E Purgatto, Heng Yin. A Valletta, G Pasqua. Chitosan oligosaccharides affect xanthone and VOC biosynthesis in Hypericum perforatum root cultures and enhance the antifungal activity of root extracts. Plant Cell Reports. 2018, 37(11): 1471-1484.
44 Jinxia He, Ruixin Li, Xue Sun, Wenxia Wang, Jianen Hu, HongguoXie, Heng Yin. Effects of Calcium Alginate Submicroparticles on Seed Germination and Seedling Growth of Wheat (Triticum aestivum L.). Polymers. 2018, 10: 1154.
43 Hailong Cao, Min Yue, Gang Liu, Yuguang Du, Heng Yin, Microbial production of mannitol by Lactobacillus brevis 3-A5 from concentrated extract of Jerusalem artichoke tubers. Biotechnology and Applied Biochemistry. 2018, 65(3): 484-489.
2017及以前
42 Qingsong Xu, Meisi Liu, Qishun Liu, Wenxia Wang, Yuguang Du, Heng Yin. The inhibition of LPS-induced inflammation in RAW264.7 macrophagesvia the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide. Carbohydrate Polymers. 2017, 174: 1138-1143.
41 Qingsong Xu, Wenjing Wang, Chen Qu, Jianguo Gu, Heng Yin, Zhihao Jia, Linsheng Song, Yuguang Du, Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure. Carbohydrate Polymers. 2017, 170: 241-246.
40 Wei Lei, Dangdang Wang, Tongyi Dou, Jie Hou, Liang Feng, Heng Yin, Qun Luo, Jie Sun, Guangbo Ge, Ling Yang, Assessment of the inhibitory effects of pyrethroids against human carboxylesterases. Toxicology and Applied Pharmacology. 2017, 321: 48-56.
39 Rui Jia, Keyan Sun, Rongchun Li, Youyou Zhang, Wenxia Wang, Heng Yin, Dawei Fang, Quan Shi, and Z. Tan, Heat capacities of some sugar alcohols as phase change materials for thermal energy storage applications. Journal of Chemical Thermodynamics. 2017, 115: 233-248.
38 Heng Yin, Yuguang Du, Zhongmin Dong. Chitin Oligosaccharide and Chitosan Oligosaccharide: Two Similar but Different Plant Elicitors. Front Plant Science. 2016, 7: 522.
37 Xiaochen Jia, Qingshan Meng, Haihong Zeng, Wenxia Wang, Heng Yin. Chitosan oligosaccharide induces resistance to Tobacco mosaic virus in Arabidopsis via the salicylic acid-mediated signalling pathway. Scientific Report. 2016, 6: 26144.
36 Xiaohui Wang, Naiyu Chi, Fengwu Bai, Yuguang Du, Yong Zhao, Heng Yin. Characterization of a cold-adapted and salt-tolerant exo-chitinase (ChiC) from Pseudoalteromonas sp. DL-6. Extremophiles. 2016, 20(2): 167-176.
35 Likun Cheng, Qingsong Xu, KYang, Jun He, Daiwen Chen, Yuguang Du, Heng Yin. Annotation of porcine milk oligosaccharides throughout lactation by hydrophilic interaction chromatography coupled with Q-TOF tandem mass spectrometry. Electrophoresis. 2016, 37: 1525-1531.
34 Qishun Liu, Fengli Yang, Heng Yin, Yuguang Du. Conversion of saccharides into levulinic acid and 5-hydroxymethylfurfural over WO3-Ta2O5 catalysts. RSC Advances. 2016, 6: 49760-49763.
33 Xiaochen Jia, Jian Kang, Heng Yin. A simple and rapid method for measuring alpha-D-phosphohexomutases activity by using anion-exchange chromatography coupled with an electrochemical detector. PeerJ. 2016, 4: e1517.
32 Junyan Ma, Hailong Cao, Haidong Tan, Xuejun Hu, Wujun Liu, Yuguang Du, Heng Yin. Cloning, Expression, Characterization, and Mutagenesis of a Thermostable Exoinulinase from Kluyveromycescicerisporus. Appl BiochemBiotechnol. 2016, 178(1): 144-158.
31 Xiujun Zhang, Yingying Zhu, Longfei Bao, Liwei Gao, Guangshan Yao, Yanan Li, Zhifeng Yang, Zhonghai Li, Yaohua Zhong, Fuli Li, Heng Yin, Yinbo Qu, Yuqi Qin. Putative methyltransferase LaeA and transcription factor CreA are necessary for proper asexual development and controlling secondary metabolic gene cluster expression. Fungal Genetics and Biology. 2016, 94: 32-46.
30 Benwei Zhu, Meijuan Chen, Heng Yin, Yuguang Du, Liming Ning, Enzymatic Hydrolysis of Alginate to Produce Oligosaccharides by a New Purified Endo-Type Alginate Lyase. Mar Drugs. 2016, 14: 108.
29 Yunbin Fu, Likun Cheng, Yanyu Meng, Shuguang Li, Xiaoming Zhao, Yuguang Du, Heng Yin. Cellulosimicrobiumcellulans strain E4-5 enzymatic hydrolysis of curdlan for production of (1→3)-linked β-D-glucan oligosaccharides. Carbohydrate Polymers. 2015, 134: 740-744.
28 Mengyu Wang, Yinchao Chen, Rui Zhang, Wenxia Wang, Xiaoming Zhao, Yuguang Du, Heng Yin. Effects of chitosan oligosaccharides on the yield components andproduction quality of different wheat cultivars (Triticum aestivum L.) in Northwest China. Field Crops Research. 2015, 172: 11–20.
27 Yubin Fu, Mengyu Wang, Wenxia Wang, YaqinTuo, Zhimou Guo, Yuguang Du, Heng Yin. (1→3)-β-D-glucan oligosaccharides monomers purification and its H2O2 induction effect study. International Journal of Biological Macromolecules. 2015, 81:1069-1073.
26 Huiyan Zhang, Yong Zhao, Hailong Cao, GuangqingMou,Heng Yin. Expression and characterization of a lytic polysaccharide monooxygenase from Bacillus thuringiensis. International Journal of Biological Macromolecules. 2015, 79: 72–75.
25 Jianping Zhang, Hailong Cao, Shuguang Li, Yong Zhao, Wenxia Wang, Qingsong Xu, Yuguang Du, Heng Yin. Characterization of a new family 75 chitosanase from Aspergillus sp. W-2. International Journal of Biological Macromolecules. 2015, 81: 362-369.
24 Benwei Zhu, Haidong Tan, Yuqi Qin, Qingsong Xu, Yuguang Du, HengYin. Characterization of a newendo-type alginate lyase from Vibrio sp. W13. International Journal of Biological Macromolecules. 2015, 75: 330-337.
23 Benwei Zhu, Heng Yin. Alginate lyase: Review of major sources and classification, properties, structure-function analysis and applications. Bioengineered. 2015, 6(3): 125-131 (Cover story).
22 Benwei Zhu，Lishuxin Huang，Haidong Tan，Yuqi Qin，Yuguang Du，Heng Yin. Characterization of a new endo-type polyM-specific alginate lyase from Pseudomonas sp. Biotechnology Letters. 2015, 37: 409-415.
21 Likun Cheng, Lunxue Wang, Qingsong Xu, Linjuan Huang, DS Zhou, Zhi Li, Shuguang Li, Yuguang Du, Heng Yin. Chitooligosaccharide supplementation improves the reproductive performance and milk composition of sows. Livestock Science. 2015, 174: 74-81.
20 Anders Kjar, Heng Yin, Francel Verstappen, Harro Bouwmeester, Elise Ivarsen, Xavier Fretté, Lars Porskjær Christensen, Kai Grevsen, Martin Jensen. Week long effects of applied stress on the production of artemisinin and precursors in Artemisia annua L. plants. Journal of Plant Biology Research. 2015, 4(2): 83-93.
19 Xiaohui Wang, Yong Zhao, Haidong Tan, Naiyu Chi, Qingfang Zhang, Yuguang Du, Heng Yin. Characterisation of a chitinase from Pseudoalteromonas sp. DL-6, a marine psychrophilic bacterium. International Journal of Biological Macromolecules. 2014, 70: 455–462.
18 Yu Li, Qiongsong Xu, Peng Wei, Likun Cheng, Qiang Peng, Shuguang Li, Heng Yin, Yuguang Du. Chitosan oligosaccharides negatively regulate MAP kinase signaling to ablate the expressions of E-selectin and ICAM-1 induced by LPS in endothelial cells. International Journal of Molecular Medicine. 2014, 33(2): 392-400.
17 Yunhong Zhang, Heng Yin, Xiaoming Zhao, Wenxia Wang, Yuguang Du, Ailing He, Kegang Sun. The promoting effects of alginate oligosaccharides on root development in Oryza sativa L. mediated by auxin signaling. Carbohydrate Polymers. 2014, 113: 446-454.
16 Qiang Peng, Qingsong Xu, Heng Yin, Linjuan Huang, Yuguang Du. Characterization of an immunologically active pectin from the fruits of Lyciumruthenicum. International Journal of Biological Macromolecules. 2014, 64: 69–75.
15 Heng Yin, Yan Li, Hongyan Zhang, Wenxia Wang, Hang Lu, Kai Grevsen, Xiaoming Zhao, Yuguang Du. Chitosan Oligosaccharides-Triggered Innate Immunity Contributes to Oilseed Rape Resistance against Sclerotinia Sclerotiorum. International Journal of Plant Sciences. 2013, 174(4): 722-732 (Cover story).
14 Hang Liu, Yunhong Zhang, Heng Yin, Wenxia Wang, Xiaoming Zhao, Yuguang Du. Alginate oligosaccharides enhanced Triticum aestivum L. tolerance to drought stress. Plant Physiology and Biochemistry. 2013, 62: 33-40.
13 Yunhong Zhang, Hang Liu, Heng Yin, Wenxia Wang, Xiaoming Zhao, Yuguang Du. Nitric oxide mediates alginate oligosaccharides induced root development in wheat (Triticum aestivum L.). Plant Physiology and Biochemistry. 2013, 71: 49-56.
12 Yunhong Zhang, Heng Yin, Hang Liu, Wenxia Wang, Lishu Wu, Xiaoming Zhao, Yuguang Du. Alginate oligosaccharides regulate nitrogen metabolism via calcium in Brassica campestris L. var. utilis Tsen et Lee. Journal of Horticultural Science & Biotechnology. 2013, 88(4): 502-508.
11 Yunhong Zhang, Wenxia Wang, Xiaoming Zhao, Yuguang Du. Lishu Wu. Enhancement in photosynthesis characteristics and phytohormones of flowering Chinese cabbage (Brassica campestris L. var. utilis Tsen et Lee) by exogenous alginate oligosaccharides. International journal of food, agriculture and environment. 2013, 11(1): 669-675.
10 Heng Yin, Xavier C Fretté, Lars P Christensen, Kai Grevsen. Chitosan Oligosaccharides Promote the Content of Polyphenols in Greek Oregano (Origanum vulgare ssp. hirtum). Journal of Agricultural and Food Chemistry. 2012, 60(1): 136-143.
9 Heng Yin, Anders Kjaer, Xavier C. Fretté, Yuguang Du, Lars P. Christensen, Martin Jensen, Kai Grevsen. Chitosan oligosaccharide and salicylic acid up-regulate gene expression differently in relation to the biosynthesis of artemisinin in Artemisia annua L. Process Biochemistry. 2012, 47(11): 1559-1562.
8 Weihua Guo, Heng Yin, Zhiqiang Ye, Xiaoming Zhao, Jingli Yuan, Yuguang Du. A comparison study on the interactions of two oligosaccharides with tobacco cells by time-resolved fluorometric method. Carbohydrate Polymers. 2012, 90: 491-495.
7 Hongyan Zhang, Wenxia Wang, Heng Yin, Xiaoming Zhao, Yuguang Du. Oligochitosan induces programmed cell death in tobacco suspension cells. Carbohydrate Polymers. 2012, 87(3): 2270-2278.
6 Yunbin Fu, Heng Yin, Wenxia Wang, Mengyu Wang, Hongyan Zhang, Xiaoming Zhao, Yuguang Du. beta-1, 3-Glucan with different degree of polymerization induced different defense responses in tobacco. Carbohydrate Polymers. 2011, 86(2): 774-782.
5 Hongyan Zhang, Xiaoming Zhao, Jinli Yang, Heng Yin, Wenxia Wang, Hang Lu, Yuguang Du. Nitric oxide production and its functional link with OIPK in tobacco defense response elicited by chitooligosaccharide. Plant Cell Reports. 2011, 30(6): 1153-1162.
4 Jinli Yang, Heng Yin, Hang Lu, Xiaoming Zhao, Yuguang Du Molecular cloning, prokaryotic expression, and purification of an alternatively spliced oligochitosan-induced Ser/Thr protein kinase in tobacco. Israel Journal of Plant Sciences. 2010, 58(1): 67-75.
3 Heng Yin, Yuguang Du, Junzeng Zhang. Low Molecular Weight and Oligomeric Chitosans and Their Bioactivities. Current Topics in Medicinal Chemistry. 2009, 9(16): 1546-1559.
2 Yan Li, Heng Yin, Qing Wang, Xiaoming Zhao, Yuguang Du, Fenglan Li. Oligochitosan induced Brassica napus L. production of NO and H2O2 and their physiological function. Carbohydrate Polymers. 2009, 75(4): 612-617.
1 Heng Yin, Shuguang Li, Xiaoming Zhao, Yuguang Du, Xiaojun Ma. cDNA microarray analysis of gene expression in Brassica napus treated with oligochitosan elicitor. Plant Physiology and Biochemistry. 2006, 44(11): 910-916.
国际会议报告
1.Oct 2019 Guiyang China, The 2ndInternational Conference on Green plant Protection Innovation, Oral report.
2.Sep 2019 Milan Italy, 25th International Symposium on Glycoconjugates, Oral report.
3.Jun 2018 Kyoto Japan, The 15th Japan-China-Korea Joint Symposium on Enzyme, Oral report.
4.Jun 2018 Qingdao China, The 11th International Symposium on Glycosyltransferases , Oral report.
5.May 2018 Hainan China, The International Conference on Green plant Protection Innovation, Oral report
6.May 2018 Beijing China, The First International Congress of Biological control, Oral report.
7.Jun 2017 Reims, France,1st International Symposium on Plant Bioproduction Sciences and Technologies, Oral report.
8.Aug 2017 Jeju Korea, 24th International Symposium on Glycoconjugates, Oral report.
9.Sep 2015 Split Croatia, 23rd International Symposium on Glycoconjugates, Oral report.
10.Aug 2015 Qingdao China, 3rd International Conference on Coastal Biotechnology, Oral report.
11.Nov 2014 Jeju Korea, The 13th China-Japan-Korean Joint Symposium on Enzyme Engineering, Oral report.
主持的主要科研项目（近五年）
1.辽宁省海洋经济发展项目“海洋多糖资源高值化利用关键技术研究及功能产品开发”，2022.4-2024.4；
2.“一带一路”国际科学组织联盟（ANSO）联合研究合作专项“新型糖类农用制剂在一带一路国家种植业的应用示范”，2021.6-2023.6；
3.大连市科技创新基金计划重点学科重大课题“糖类生物质利用”，2020.7-2023.6；
4.国家自然科学基金面上项目“拟南芥胞外含LysM结构域蛋白（AtLysMe）强化几丁寡糖信号识别的作用机制研究”，2020.1-2023.12；
5.中国科学院青年创新促进会优秀会员，2020.1-2022.12；
6.中国科学院重点部署项目课题“耐盐碱经济作物功能性食品研发与产业化示范”，2020.1-2021.6；
7.国家自然科学基金面上项目“含CBM1结构域的多糖裂解单加氧酶鉴定及其底物结合机制研究”，2017.1-2020.12；
8.国家重点研发计划课题“功能糖类免疫调控技术及产品开发”, 2017.07-2020.12；
9.中国科学院科技服务网络计划“集成与示范绿色生物防控减肥减药技术”, 2018.08-2019.12；
10.中国科学院科技服务网络计划“新型糖类与微生物农药及抗逆剂创制及示范”，2016.1-2017.12；
11.大连市杰出青年科技人才“新型海洋寡糖农用制剂研发及应用推广”，2016.1-2018.12；
12.国家自然科学基金面上项目“拟南芥磷酸N-乙酰氨基葡萄糖变位酶功能鉴定及其影响蛋白糖基化的研究”，2014.1-2017.12。
兴趣爱好
1.足球：既看且踢。罗马、瓦伦西亚、西汉姆联、斯图加特和本地俱乐部球迷。
2.阅读：偏好历史、科幻与推理小说，属意作家为田中芳树、阿西莫夫。